TABLE 2.
Sensitivity and specificity or Methylation positivity rate of methylation diagnosis methods.
| Diagnosis method | HPV status | Function | Sensitivity and specificity/Methylation positivity rate | References |
| DAPK1 methylation detection | HPV-positive and negative | Diagnose cervical cancer | Sensitivity: 59% Specificity: 97% | Wang et al., 2018 |
| DAPK1 and MGMT methylation detection | HPV-positive and negative | Diagnose cervical cancer | Sensitivity: 43.4% Specificity: 68.6% | Sun et al., 2015 |
| CADM1 promoter Methylation and plasma D-dimer levels | HPV-positive | Metastasis prediction | Sensitivity: 80.4% Specificity: 90.5% | Rong et al., 2019 |
| CADM1, MAL and miR124 methylation detection with positive hrHPV test | HPV-positive | Diagnose HSIL/CIN2-3 and cervical cancer | Sensitivity: 80.7% Specificity: 85.1% | Del Pino et al., 2019 |
| FAM19A4/miR124-2 methylation detection | HPV-positive and negative | Diagnose high-risk HPV case | Methylation positivity rate of hrHPV-positive samples: 98.3% Methylation positivity rate of hrHPV-negative samples: 90.0% | Vink et al., 2019 |
| PAX1 methylation detection | HPV-positive and negative | Diagnose CIN3+ | Sensitivity: 77% Specificity: 92% | Nikolaidis et al., 2015 |
| PAX1 methylation detection with HPV16/18 test | HPV-positive | Diagnose CIN3+ | Sensitivity: 89.2% Specificity: 76.0% | Liou et al., 2016 |
| PAX1 methylation detection with Pap smearing test | HPV-positive and negative | Diagnose CIN3+ | Sensitivity: 93% Specificity: 84% | Lai et al., 2014 |
| ZNF582 methylation detection with HPV16/18 test | HPV-positive | Diagnose CIN3+ | Sensitivity: 85.4% Specificity: 80.1% | Liou et al., 2016 |
| SOX1 methylation detection with Pap smearing test | HPV-positive and negative | Diagnose CIN3+ | Sensitivity: 96% Specificity: 71% | Lai et al., 2014 |
| LMX1A methylation detection | HPV-positive and negative | Diagnose CIN3+ | Sensitivity: 77% Specificity: 88% | Lai et al., 2010 |
| SIM1 methylation detection in plasma ccfDNA | HPV-positive and negative | Diagnose cervical cancer | Sensitivity: 38.5% Specificity: 100% | Kim et al., 2018 |
| SIM1 methylation detection in cervical brush specimens | HPV-positive and negative | Diagnose CIN3+ | Methylation positivity rate: 85% | Kim et al., 2018 |
| ASCL1, LHX8 and ST6GALNAC5 methylation detection in lavage self-samples | HPV-positive | Diagnose CIN3+ | Sensitivity: 74% Specificity: 79% | Verlaat et al., 2018a |
| ASCL1, LHX8 and ST6GALNAC5 methylation detection in brush self-samples | HPV-positive | Diagnose CIN3+ | Sensitivity: 88% Specificity: 81% | Verlaat et al., 2018a |
| FAM19A4, GHSR, PHACTR3, PRDM14, SST and ZIC1 methylation detection in urine samples | HPV-positive and negative | Diagnose cervical cancer | Methylation positivity rate: 97% | Snoek et al., 2019a |