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Acetylation of streptothricin. (A) Chemical structure of streptothricin showing the site of acetylation on the β-lysine. (B) Model of SatA (PDB accession number 3PP9) in complex with streptothricin (yellow). A conserved tyrosine (Y164, blue) appears to be in close proximity to a hydrogen bond with streptothricin. A conserved aspartate (D160, orange) is important for dimerization. (Adapted from reference 98.)
