Table 2.

Clinical application of PSMA–PET/CT

Primary staging	Comparison with mpMRI is preferable because low spatial resolution and artifact given by excreted tracer
Secondary staging	Accuracy depends on serum PSA level
Diagnosis of biochemical recurrence	Accuracy depends on serum PSA level, Biochemical progression-free survival
Treatment planning	Delineation of CTV to include potential occult tumor for SRT
Response evaluation	RLT with alpha- or beta-emitting radionucleotides

Abbreviations: PSMA, prostatic specific membrane antigen; mpMRI, multiparametric magnetic resonance imaging; PSA, prostate specific antigen; CTV, clinical target volume; SRT, stereotactic radiotherapy; RLT, radioligand therapy.