Table 4.
Analysis of mediators according to the ICS dose category
| Variable (Pg/ml) | Low ICS dose | Middle ICS dose | High ICS dose | P value |
|---|---|---|---|---|
| IL-35 (ng/ml) | 3.33 (2.63, 7.40) | 6.25 (3.13, 24.16) | 6.51 (3.67, 30.63) | NS |
| IL-1β (pg/ml) | 27.28 (6.31, 234.25) | 37.53 (12.7, 109.23) | 76.57 (7.88, 547.4) | NS |
| IL-6 (pg/ml) | 7.06 (2.93, 62.01) | 10.56 (3.99, 30.15) | 11.67 (3.67, 104.88) | NS |
| IL-8 (pg/ml) | 2449 (8, 5891) | 3248 (558, 11,186) | 1861 (54, 9775) | NS |
| IL-10 (pg/ml) | 0.74 (0.51, 1.25) | 0.83 (0.52, 1.58) | 0.78 (0.53, 1.22) | NS |
| IL-17A (pg/ml) | 5.76 (0.32, 12.24) | 6.77 (1.73, 17.12) | 5.57 (1.39, 13.7) | NS |
| IL-23 (pg/ml) | 6.43 (3.57, 19.78) | 10.11 (3.57, 24.93) | 4.89 (2.19, 10.11) | NS |
| TNF-α (pg/ml) | 2.64 (1.34, 6.29) | 3.74 (1.7, 7.63) | 2.71 (1.87, 16.13) | NS |
| MCP-1 (pg/ml) | 97.8 (5.5, 241.5) | 115.8 (16.8, 273.7) | 228.3 (98.4, 1062.1) | NS |
Data are expressed as median (IQR). Data were analyzed using a Kruskal-Wallis test. ICS inhaled corticosteroid, NS non-significant, IL Interleukin, TNF Tumor necrosis factor, MCP monocyte chemoattractant protein