Table 2.
Amino acid sequences of mimotopes, peptides, and their derivatives for immunization
| Mimotope ID |
Mimotope: Amino acid sequences including GGGS linker |
Mimotope-KLH: Mimotope-keyhole limpet hemocyanin fusions for immunization protocol 1 |
Mimotope-AQP4268–285: Mimotopes fused with AQP4-reactive T cell epitope used for immunization protocol 2 |
|---|---|---|---|
| I-04 | WRYHVHPTPFKSGGGS | WRYHVHPTPFKSGGGSC- keyhole limpet hemocyanin | WRYHVHPTPFKSKAAQQTKGSYMEVEDNRS |
| I-13 | GPFHFLHHHWSQGGGS | GPFHFLHHHWSQGGGSC- keyhole limpet hemocyanin | GPFHFLHHHWSQKAAQQTKGSYMEVEDNRS |
| I-18 | WSSHAHRHNHFRGGGS | – | |
| IV-04 | WPWHAHGNTRGIGGGS | WPWHAHGNTRGIGGGSC- keyhole limpet hemocyanin | WPWHAHGNTRGIKAAQQTKGSYMEVEDNRS |
| IV-27 | IQYAPGGSYSVIGGGS | – | |
| IV-38 | VKGHWHHLNHANGGGS | – | VKGHWHHLNHANKAAQQTKGSYMEVEDNRS |
| II-01 | FPFWHRTHAWDRGGGS | – | |
| III-01 | WSWKHHHPIMPRGGGS | WSWKHHHPIMPRGGGSC-keyhole limpet hemocyanin | WSWKHHHPIMPRKAAQQTKGSYMEVEDNRS |
|
“mix”: I-04 (WRYHVHPTPFKSGGGSC- keyhole limpet hemocyanin) + I-13 (GPFHFLHHHWSQGGGSC- keyhole limpet hemocyanin) + IV-04 (WPWHAHGNTRGIGGGSC- keyhole limpet hemocyanin) + III-01 (WSWKHHHPIMPRGGGSC-keyhole limpet hemocyanin) |
– | ||
| Neg.controls: | – | – | |
| II-17 | HFWGHHRTTSKVGGGS | – | – |
| random peptide L5 | SPRAISSYPLNEGGGS | – | – |
| random peptide L8 | FPTDSLRGDVGMGGGS | – | – |
There are no matching linear sequences of the mimotopes to human AQP4 loops A (TINWGGTEKPLPVD), C (TPPSVVGGLGVTMVHGNLT) or E (NWENHW)
Loop sequences were taken from [29]