Table 3.

Antibody titers obtained with immunization protocol 2

Mimotope (n = number of rats)	Titer Anti-rat AQP4	Titer Anti-human AQP4	Considered antibody-positive according to cut-off criteria***
III-01 (n = 8)	20	0
∆	0	20
	10	0
	80	20	***
	0	0
	40	20	***
	0	0
	160	40	***
IV-38 (n = 4)	5	10
	0	0
	0	0
	0	0
I-13 (n = 5)	0	0
	320	80	***
	160	0	***
	40	10	***
	0	0
I-04 (n = 5)	40	10	***
	20	20
	320	160	***
	40	40	***
∆	320	80	***
IV-04 (n = 5)	80	10	***
	0	0
	160	0	***
	160	40	***
	10	0

***Titers considered positive when single values for anti-rat AQP4 or anti-human AQP4 > 20

∆ Serum used for staining of rat astrocytes (Supplementary information S6)