Table 4.

Semiquantitative analysis of immunoglobulin G isotypes among AQP4-reactive antibodies raised in mimotope-AQP4_268–285-immunized Lewis rats

	IgG1	IgG2a	IgG2b	IgG2c
IV-04	+	+	+	+
III-01	+(+)	+++	+++	+(+)
I-04	+	++(+)	+(+)	+
I-13	++(+)	++	++	++

+ to +++ indicate reactivity of immunoglobulin G isotype-specific antibodies to AQP4-reactive antibodies from mimotope-AQP4_268–285-immunized Lewis rats bound to HEK293 cells expressing rat AQP4-EmGFP. The reactivity was rated as + (weak), ++ (moderate), and +++ (strong), respectively