Table 5.

Sequence homology between different mimotopes and bacterial/fungal/parasitic proteins. All proteins are located intracellularly, but might be released as a consequence of immune-mediated damage

Mimotope	# Mimotope sequence # Quality of matcha # Organismal protein sequence #	Protein name Protein sequence ID[Organism]	Possible disease association of bacteria/fungi/parasites or presence in human microbiome
III-01	5 HHHPIMPR 12 HH + PIMPR 183 HHQPIMPR 190	DUF3306 domain-containing protein WP_083797754.1 [Vibrio Metschnikovii].	Infections [42, 43]; Isolated cases of pneumonia [44].
	5 HHHPIMPR 12 HHHPI + PR 160 HHHPILPR 167	N-succinylarginine dihydrolase WP_058459851.1 [Fluoribacter bozemanae = Legionella bozemanae] Same alignment seen for Legionella anisa and Legionella longbeachae	Legionellosis [45, 46].
I-04	3 YHVHPTPF 10 Y + VHPTPF 519 YQVHPTPF 526	Hypothetical protein CORT_0F01650 XP_003870521.1 [Candida orthopsilosis Co 90–125]	Rare infections [47]
	3 YHVHPTP 9 YHVHPTP 560 YHVHPTP 566 6 HPTPFK 11 +PTPFK 57 QPTPFK 62	Vacuolar sorting-associated protein EGC49414.1 [Histoplasma capsulatum H88];Same alignment seen forvacuolar protein sorting-associated protein 27 EER41546.1 [Histoplasma capsulatum H143] Hypothetical protein WP_080024432.1 [Helicobacter pylori]	Histoplasmosis [48] Gastritis, peptid ulcers [49]
I-13	2 PFHFLHH 8 PFHFLHH 3450 PFHFLHH 3456 7 HHHWSQ 12 HHHWS+ 245 HHHWSH 250	RAVE 1 carboxy-terminal protein RQX74768.1 [Toxoplasma gondii] Chain A, Enoyl-CoA hydratase/isomerase family protein 4HC8_A [Mycobacterium tuberculosis]	Toxoplasmosis [50] Tuberculosis [51]
IV-04	1 WPWHAH-GNTRGI 12 WPWHAH GN R I 119 WPWHAHLGN-RVI 130 1 WPWHAHGN 8 W WHAHGN 393 WAWHAHGN 400 1 WPWHAHGNTR 10 W WHAHGN R 243 W-WHAHGNSR 251 4 HAHGNTRGI 12 HA GNTRG+ 252 HARGNTRGV 260 5 AHGNTRGI 12 A + GNTRG+ 253 AQGNTRGV 260 1 WPWHAHGN 8 W WHAHGN 123 WRWHAHGN 130	Glycosyltransferase family 2 protein WP_040707114.1 [Nocardia takedensis]; Same alignment seen in [Nocardia pneumoniae] Gentisate 1,2-dioxygenase VFT64169.1 [Pseudomonas aeruginosa] MFS transporter WP_115184045.1 [Serratia multispecies, among them S. plymuthica, S. quinivorans, S. proteamaculans, S. liquefaciens, S. grimesii] Hop family adhesin BabA CEI71366.1 [Helicobacter pylori] Hop family adhesin BabA WP_000716277.1 [Helicobacter pylori] cupin domain-containing protein, partial WP-129361314.1 [Enterobacter cloacae complex sp. 2DZ2F16B1]	Nocardiosis [52] Different types of infections [53] Different types of infections [54] Gastritis, peptid ulcers [49] Gastritis, peptid ulcers [49] Complex includes common nosocomial pathogens capable of producing a wide variety of infections [55]

Homology searches were made with the basic local alignment search tool (BLAST) and the dodecamer mimotope sequences as input. The combined results of the following searches were pooled for this table: unlimited search, search limited to H. pylori (taxid: 210), search limited to Mycobacterium tuberculosis typus humanus (taxid: 1773), and search limited to RNA viruses (taxid: 2559587). The limited searches were done due to possible associations of NMOSD with infections by H.pylori [56], M. tuberculosis [57–60], and Hepatitis viruses (RNA viruses] [61–63]. The top Blast Hits on 100 subject sequences were analyzed. As cut-off criteria, only continuous sequences ≥5 amino acids plus ≥1 flanking identical amino acid or positive match were considered

# represent the position of the amino acids in the mimotope or protein sequence

^aamino acids found in both sequences are indicated by letters

+ = positive match (conservative substitution)

white space = match with zero/negative score

- = gap