Table 1.
Baseline characteristics between CW and Non-CW IPAH patients
| Variables | Total (n = 55) | CW (n = 13) | Non-CW (n = 42) | P Value |
|---|---|---|---|---|
| Age, years | 31 ± 9 | 34 ± 8 | 30 ± 10 | 0.11 |
| Female, n (%) | 46(83.6) | 11(84.6) | 35(83.3) | 1.0 |
| BMI, kg/m2 | 22.6 ± 3.0 | 21.7 ± 2.5 | 22.9 ± 3.1 | 0.18 |
| WHO-FC III-IV, n (%) | 27(49.1) | 9(69.2) | 18(42.8) | 0.12 |
| Laboratory tests | ||||
| Creatinine, μmol/l | 71.3 ± 15.2 | 74.1 ± 18.8 | 70.5 ± 14.0 | 0.46 |
| Uric acid, μmol/l | 443.2 ± 131.0 | 469.7 ± 172.1 | 435.0 ± 116.8 | 0.41 |
| HsCRP, mg/l | 1.7 ± 1.6 | 1.5 ± 1.5 | 1.8 ± 1.6 | 0.44 |
| NT-proBNP, pg/ml | 1181.8 ± 1102.3 | 1389.4 ± 1505.2 | 1117.6 ± 958.8 | 0.84 |
| ET-1, fmol/ml | 0.5 ± 0.6 | 0.7 ± 0.8 | 0.5 ± 0.5 | 0.62 |
| HE4, ng/ml | 6.9 ± 2.2 | 8.8 ± 2.5 | 6.3 ± 1.7 | 0.001 |
| Hemodynamics | ||||
| RAP, mmHg | 4.9 ± 4.7 | 8.0 ± 5.1 | 4.0 ± 4.2 | 0.01 |
| mPAP, mmHg | 50.1 ± 10.6 | 51.5 ± 9.0 | 49.7 ± 11.0 | 0.59 |
| PCWP, mmHg | 6.6 ± 2.8 | 7.2 ± 2.9 | 6.4 ± 2.8 | 0.30 |
| PVR, Wood units | 10.8 ± 4.7 | 12.3 ± 5.3 | 10.3 ± 4.5 | 0.19 |
| CI, L·min−1·m−2 | 2.8 ± 0.9 | 2.5 ± 0.6 | 2.9 ± 0.9 | 0.23 |
| SvO2, % | 70.5 ± 7.3 | 68.7 ± 6.7 | 71.0 ± 7.4 | 0.47 |
CW Clinical worsening, IPAH Idiopathic pulmonary arterial hypertension, BMI Body mass index, WHO-FC World Health Organization functional class, HsCRP High sensitive C-reactive protein, NT-proBNP N-terminal prohormone brain natriuretic peptide, ET-1 Endothelin-1, HE4 Human epididymis protein 4, RAP Right atrial pressure, mPAP Mean pulmonary arterial pressure, PCWP Pulmonary capillary wedge pressure, PVR Pulmonary vascular resistance, CI Cardiac index, SvO2 Mixed venous oxygen saturation