Table 2.
35 differential expressed metabolites in p53-wt vs.p53-KO HBE cells post 4 Gy radiation
| Metabolites | VIP* | log2 (FC) | p-value | Class | Sub class |
|---|---|---|---|---|---|
| Erythronic acid lactone | 1.06922 | 0.6158 | 6.9E−05 | Lactones | Organoheterocyclic compounds |
| Hydroxylamine | 1.34941 | 0.19798 | 0.04045 | Homogeneous other non-metal compounds | Homogeneous non-metal compounds |
| 4-hydroxymandelic acid | 1.36889 | − 0.6996 | 0.00142 | Phenols | Benzenoids |
| Erythronic acid | 1.42277 | − 1.7093 | 0.00929 | Organooxygen compounds | Organic oxygen compounds |
| Epsilon-caprolactam | 1.34602 | − 0.7127 | 0.00061 | Lactams | Organoheterocyclic compounds |
| Allothreonine | 1.46924 | − 0.5049 | 0.00792 | Carboxylic acids and derivatives | Organic acids and derivatives |
| Metharbital | 1.41033 | − 1.0301 | 0.00381 | Diazines | Organoheterocyclic compounds |
| Nicotinic acid | 1.42734 | − 0.5283 | 0.00083 | Pyridines and derivatives | Organoheterocyclic compounds |
| 3,3-dimethyl-1-hydroxy-cyclohexene | 1.009 | − 1.3095 | 0.00151 | – | – |
| Cyanoalanine | 1.40793 | − 0.7455 | 9.4E−05 | – | – |
| 2,4-diaminobutyric acid | 1.4873 | − 0.793 | 0.03173 | Carboxylic acids and derivatives | Organic acids and derivatives |
| Isocitric acid | 1.43121 | − 1.3229 | 0.01103 | Carboxylic acids and derivatives | Organic acids and derivatives |
| Alpha-tocopherol | 1.47328 | − 1.0729 | 0.00435 | Prenol lipids | Lipids and lipid-like molecules |
| Arbutin | 1.06715 | − 1.2865 | 0.00725 | Organooxygen compounds | Organic oxygen compounds |
| 5-hydroxymethyl-2-furoic acid | 1.38372 | − 2.0063 | 0.00456 | Furans | Organoheterocyclic compounds |
| Alloxanoic acid | 1.15251 | − 2.265 | 0.0279 | – | – |
| 3-hydroxybenzoic acid | 1.4286 | − 1.47 | 0.00704 | Benzene and substituted derivatives | Benzenoids |
| 4-hydroxyphenylacetic acid | 1.34886 | − 0.7195 | 0.01778 | Phenol esters | Benzenoids |
| Succinylacetone | 1.00743 | − 3.6389 | 0.01924 | Keto acids and derivatives | Organic acids and derivatives |
| Chlorogenic acid | 1.01029 | − 2.1308 | 0.00706 | Organooxygen compounds | Organic oxygen compounds |
| Tocopherol acetate | 1.3993 | − 1.8671 | 0.01908 | Prenol lipids | Lipids and lipid-like molecules |
| Pseudo uridine | 1.24524 | − 0.4121 | 0.03491 | Nucleoside and nucleotide analogues | Nucleosides, nucleotides, and analogues |
| Epicatechin | 1.37918 | − 0.9262 | 0.01609 | Flavonoids | Phenylpropanoids and polyketides |
| O-phosphoethanolamine | 1.37653 | 0.87116 | 0.04621 | Organic phosphoric acids and derivatives | Organic acids and derivatives |
| Azelaic acid | 1.13179 | − 1.3106 | 0.00278 | Fatty Acyls | Lipids and lipid-like molecules |
| Beta-glutamic acid | 1.22441 | − 0.4523 | 0.03566 | – | – |
| Lactobionic acid | 1.34112 | − 1.0772 | 0.01633 | – | – |
| Arsenate | 1.03192 | − 1.9182 | 0.00398 | Miscellaneous mixed metal/non-metals | Mixed metal/non-metal compounds |
| Palatinitol | 1.27221 | − 0.7068 | 0.0263 | – | – |
| L-allothreonine | 1.38117 | − 0.6869 | 0.04396 | Purine nucleosides | Nucleosides, nucleotides, and analogues |
| Oleamide | 1.02286 | 0.2853 | 0.01158 | Fatty Acyls | Lipids and lipid-like molecules |
| 1,3-diphosphoglycerol | 1.12954 | 1.40969 | 0.02935 | – | – |
| D-erythro-sphingosine | 1.24636 | − 0.5613 | 0.02118 | Organonitrogen compounds | Organic nitrogen compounds |
| Phytosphingosine | 1.11889 | − 0.6993 | 0.0023 | Organonitrogen compounds | Organic nitrogen compounds |
A positive value indicates up regulation and a negative value indicates down regulation
* Vip variable important in projection, The larger the VIP, the greater the contribution of this variable to the grouping; log2 (FC): the ratio of the average expression amount of metabolites in the two groups of samples