Table 1. Comparative solubility of Pritelivir free and mesylate salt in the different excipients.
Excipient | Saturated solubility (mg ml–1) |
|
Pritelivir free base | Pritelivir mesylate salt | |
Water | BLOQ a | 1.2 |
pH 3.5 buffer | 0.1 mg | 1.3 |
pH 4.5 buffer | 0.1 | 0.4 |
pH 5.5 buffer | 0.1 | 0.2 |
pH 7.0 buffer | 0.1 | BLOQ a |
aBLOQ: below limit of detection.