Table 2. Comparative solubility of Pritelivir free and mesylate salt in the different excipients.
| Excipient | Saturated solubility (mg ml–1) |
|
| Pritelivir free base | Pritelivir mesylate salt | |
| Ethanol | 0.3 | 0.7 |
| Isopropanol | 0.4 | BLOQ a |
| Benzyl alcohol | 2.2 | 2.0 |
| Phenoxyethanol | 2.2 | 10.7 |
| PEG 400 | 78.7 | 10.1 |
| Dimethyl isosorbide | 82.3 | BLOQ |
| Propylene glycol | 28.4 | 4.7 |
| Transcutol P | 44.8 | 1.3 |
| Oleyl alcohol | 0.1 | BLOQ |
| Glycerin | 0.5 | 13.1 |
| Isopropyl myristate | 0.1 | — b |
| Isopropyl palmitate | BLOQ | — |
| Crodamol GTC | 0.2 | BLOQ |
aBLOQ: below limit of detection.
bNo peak detected.