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. 2019 Aug 9;10(11):1867–1870. doi: 10.1039/c9md00233b

Table 2. Comparative solubility of Pritelivir free and mesylate salt in the different excipients.

Excipient Saturated solubility (mg ml–1)
Pritelivir free base Pritelivir mesylate salt
Ethanol 0.3 0.7
Isopropanol 0.4 BLOQ a
Benzyl alcohol 2.2 2.0
Phenoxyethanol 2.2 10.7
PEG 400 78.7 10.1
Dimethyl isosorbide 82.3 BLOQ
Propylene glycol 28.4 4.7
Transcutol P 44.8 1.3
Oleyl alcohol 0.1 BLOQ
Glycerin 0.5 13.1
Isopropyl myristate 0.1 b
Isopropyl palmitate BLOQ
Crodamol GTC 0.2 BLOQ

aBLOQ: below limit of detection.

bNo peak detected.