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. 2020 Apr 9;14:87. doi: 10.3389/fncel.2020.00087

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Copyright © 2020 Xiang, Lu, Wei, Cai, Wang, Liang, Xu, Wang, Liu, Wang, Liang, Li and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Berberine (BBR) restores dihydrotestosterone (DHT)-mediated estrogen receptor β/superoxide dismutase 2 (ERb/SOD2)/SOD2 suppression by androgen receptor (AR) suppression in human neurons. The human ACS-5003 neurons were treated by control (CTL), DHT (10 nM), DHT with AR knockdown by lentivirus (DHT/shAR), CTL with AR overexpression by lentivirus (CTL/↑AR), CTL with 10 μM BBR (CTL/BBR), or DHT with BBR (DHT/BBR) for 24 h, then the cells were harvested for further analysis. (A) mRNA levels for AR, ERβ and SOD2 by qPCR, n = 4. (B) Quantitation of protein levels, n = 5. (C) Representative western blotting pictures for (B). *P < 0.05, vs. CTL group. Data were expressed as mean ± SEM.