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. 2020 Apr 9;14:87. doi: 10.3389/fncel.2020.00087

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Copyright © 2020 Xiang, Lu, Wei, Cai, Wang, Liang, Xu, Wang, Liu, Wang, Liang, Li and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prenatal treatment of either shAR or BBR ameliorates prenatal DHT exposure-induced autism-like behavior (ALB) in offspring. The 2-month female rats received either CTL or DHT treatment, which involved either DHT with shAR lentivirus infusion in the amygdala (DHT/shAR) or DHT with BBR injection (DHT/BBR) during the 21-day pregnancy and the subsequent 2-month old male offspring were used for ALB analysis. (A) Ultrasonic vocalization, n = 9. (B) Social recognition, seconds spent socially investigating a conspecific [same conspecific in tests 1–4; novel conspecific in test 5 (a new stimulus rat was introduced)], n = 9. *P < 0.05, vs. CTL group; ^¶P < 0.05, vs. DHT group. (C,D) Three-chambered social tests, n = 8. (C) Time spent in the chamber for sociability. (D) Time spent in the chamber for social novelty. *P < 0.05, vs. CTL group. Data were expressed as mean ± SEM.