Table 1.

Base Case Clinical and Economic Outcomes for Screening From Age 45 vs 50 Years Through Age 75 Years, Including Post-Polypectomy Surveillance ThroughAge 80 Years

	Outcomes per 1000 persons ages 45–100 years
								Cost effectiveness
Strategy	CRC cases, n	CRC deaths, n	Colonoscopies, n	Stool tests, n	Sigmoidoscopies, n	QALYs per person	Cost per person	Comparator strategy	Cost per QALY gained
No screening	106	43	275	—	—	21.1645	$5146	—	—
Screening starting at age 45 years
Colonoscopy every 10 years, ages 45–75 years	28	9	4764	—	—	21.3098	$5013	Colonoscopy every 10 years, ages 50–75 years	$33,900
FIT yearly, ages 45–75 years	42	12	2194	18,253	—	21.3073	$3447	FIT yearly, ages 50–75 years	$7700
Sigmoidoscopy at 45 years; colonoscopy every 10 years, ages 50–75 years	31	10	4200	—	997	21.3047	$5047	Colonoscopy every 10 years, ages 50–75 years	$55,900
Sigmoidoscopy at 45, FIT yearly 50–75	40	11	2344	13,613	997	21.3056	$3956	FIT yearly, ages 50–75 years	$49,900
FIT yearly 45–49;colonoscopy every 10 years, ages 50–75 years	31	10	4062	4521	—	21.3033	$4554	Colonoscopy every 10 years, ages 50–75 years	$2500
Screening starting at age 50 years
Colonoscopy every 10 years, ages 50–75 years	33	10	4007	—	—	21.2954	$4526	No screening	Dominatesa
FIT yearly, ages 50–75 years	45	13	1926	15,011	—	21.2933	$3339	No screening	Dominatesa

^aMore effective and less costly than comparator. See Supplementary Materials for analysis of colonoscopy vs no screening as a function of CRC risk.