Table 3.
Association of urine markers with 24 urine oxalate excretion (Uox), CaOx supersaturation (CaOx SS), proximal tubular oxalate concentration (PTOx), urine calcium/Cr, and urine citrate/Cr, among n = 30 PH patients
| Biomarkerb | Uoxb | CaOx SS | PTOxab | Calcium/ Crab | Citrate/ Crab | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Estimate (95% CI) | P | Estimate (95% CI) | P | Estimate (95% CI) | P | Estimate (95% CI) | P | Estimate (95% CI) | P | |
| MCP-1 | −0.195 (− 0.898, 0.509) | 0.59 | 0.446 (0.207, 0.684) | <.001 | − 0.135 (− 0.769, 0.498) | 0.68 | − 0.04 (− 0.587, 0.507) | 0.89 | − 0.14 (− 0.494, 0.213) | 0.44 |
| MCP-1/Cr | 0.083 (− 0.538, 0.704) | 0.79 | 0.289 (0.084, 0.494) | 0.006 | 0.275 (− 0.301, 0.851) | 0.35 | – | – | – | – |
| Clusterin | −0.43 (− 0.981, 0.122) | 0.13 | 0.106 (− 0.342, 0.555) | 0.64 | − 0.503 (−1.031, 0.024) | 0.062 | −0.273 (− 0.804, 0.258) | 0.32 | − 0.139 (− 0.566, 0.288) | 0.52 |
| Clusterin/Cr | −0.139 (− 0.654, 0.377) | 0.60 | −0.168 (− 0.56, 0.223) | 0.40 | −0.161 (− 0.651, 0.328) | 0.52 | – | – | – | – |
| NGAL | −0.025 (− 0.612, 0.562) | 0.93 | 0.024 (− 0.171, 0.219) | 0.81 | −0.139 (− 0.673, 0.395) | 0.61 | −0.332 (− 0.671, 0.007) | 0.055 | 0.16 (− 0.124, 0.443) | 0.27 |
| NGAL/Cr | 0.172 (−0.386, 0.729) | 0.55 | −0.154 (− 0.35, 0.041) | 0.12 | 0.117 (− 0.407, 0.641) | 0.66 | – | – | – | – |
| 8 IP | −0.212 (− 0.439, 0.014) | 0.067 | 0.208 (0.109, 0.308) | <.001 | −0.242 (− 0.451, − 0.033) | 0.023 | 0.082 (− 0.087, 0.251) | 0.34 | −0.141 (− 0.292, 0.01) | 0.068 |
| 8 IP/Cr | 0.045 (−0.098, 0.188) | 0.54 | 0.043 (−0.021, 0.107) | 0.19 | 0.107 (−0.034, 0.249) | 0.14 | – | – | – | – |
| L-FABP | 0.011 (−0.211, 0.234) | 0.92 | 0.053 (−0.026, 0.132) | 0.19 | 0.099 (−0.118, 0.316) | 0.37 | −0.038 (− 0.163, 0.087) | 0.55 | − 0.018 (− 0.137, 0.1) | 0.76 |
| L-FABP/Cr | 0.279 (− 0.01, 0.568) | 0.059 | − 0.165 (− 0.273, − 0.058) | 0.003 | 0.421 (0.187, 0.654) | <.001 | – | – | – | – |
| OPN | 0.253 (− 0.383, 0.889) | 0.44 | 0.134 (− 0.105, 0.373) | 0.27 | − 0.019 (− 0.629, 0.591) | 0.95 | 0.03 (− 0.267, 0.327) | 0.84 | 0.22 (− 0.319, 0.759) | 0.42 |
| OPN/Cr | 0.514 (− 0.113, 1.14) | 0.11 | − 0.029 (− 0.261, 0.202) | 0.81 | 0.345 (− 0.275, 0.966) | 0.28 | – | – | – | – |
| H-FABP | 0.062 (− 0.23, 0.355) | 0.68 | 0.149 (− 0.048, 0.346) | 0.14 | 0.006 (− 0.305, 0.317) | 0.97 | − 0.067 (− 0.413, 0.279) | 0.70 | − 0.116 (− 0.335, 0.103) | 0.30 |
| H-FABP/Cr | 0.32 (0.033, 0.607) | 0.029 | − 0.024 (− 0.214, 0.166) | 0.81 | 0.353 (0.091, 0.615) | 0.008 | – | – | – | – |
P-values in bold denote significance at the 0.05 level
Models were fit using the GEE procedure with the normal distribution, identity link and exchangeable correlation specifications, unless noted otherwise
Models were adjusted for age, sex and eGFR
aOnly the urine concentrations unadjusted for creatinine were used since these variables are also adjusted for creatinine
bLog transformations were taken for all urine biomarkers as well as Uox, PTOx, Calcium/Cr and Citrate/Cr
Units of measure are Clusterin: ng/ml and μg/g Cr; NGAL: ng/ml and ng/g Cr; 8 IP: pg/ml and ng/g Cr; MCP1: pg/ml and pg/g Cr; L-FABP: ng/ml and μg/g Cr; OPN: ng/ml and μg/g Cr; H-FABP: pg/ml and ng/g Cr