Table 4.
Association of urine markers with eGFR among n = 30 PH patients
| Biomarkera | eGFR | |
|---|---|---|
| Estimate (95% CI) | P | |
| Clusterin | 1.186 (− 0.42, 2.793) | 0.15 |
| Clusterin/Cr | 1.377 (−0.347, 3.102) | 0.12 |
| NGAL | 2.598 (1.118, 4.077) | < 0.001 |
| NGAL/Cr | 2.207 (0.56, 3.855) | 0.009 |
| 8 IP | 4.586 (0.05, 9.121) | 0.054 |
| 8 IP/Cr | 2.509 (−2.34, 7.358) | 0.31 |
| MCP-1 | 1.698 (−0.569, 3.966) | 0.14 |
| MCP-1/Cr | 1.507 (−0.523, 3.536) | 0.15 |
| L-FABP | −3.542 (−10.156, 3.072) | 0.29 |
| L-FABP/Cr | −4.23 (−8.317, −0.143) | 0.043 |
| OPN | 2.543 (0.751, 4.334) | 0.005 |
| OPN/Cr | 2.223 (0.77, 3.676) | 0.003 |
| H-FABP | 1.799 (−3.621, 7.218) | 0.52 |
| H-FABP/Cr | 0.52 (−3.706, 4.746) | 0.81 |
P-values in bold denote significance at the 0.05 level
Models were fit using the GEE procedure with the normal distribution, identity link and exchangeable correlation specifications, unless noted otherwise
Models were adjusted for age and sex
aLog transformations were taken for all urine biomarkers as well as Uox, PTOx, Calcium/Cr and Citrate/Cr
Units of measure are Clusterin: ng/ml and μg/g Cr; NGAL ng/ml and ng/g Cr, 8 IP pg/ml and ng/g Cr, MCP1 pg/ml and pg/g Cr, L-FABP ng/ml and μg/g Cr, OPN ng/ml and μg/g Cr, H-FABP pg/ml and ng/g Cr