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Abnormal expression of lncRNA in HCC. a Epigenetic silencing of HCC-suppressive lncRNAs; b Epigenetic activation of HCC-promoting lncRNAs; c Transcriptional activation by HCC-related oncoproteins; d RNA processing that endows lncRNA with HCC-promoting properties; e Loss of tumor-suppressive miRNAs leads to re-expression of targeted oncogenic lncRNAs; f RBP-induced stabilization of HCC-promoting lncRNAs. RBP, RNA-binding protein
