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. 2020 Apr 15;19:77. doi: 10.1186/s12943-020-01188-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Significance of lncRNA in HCC hallmarks. Dysregulated lncRNAs promote HCC through distinct mechanisms, leading to different phenotypes corresponding to every tumor stage. These hallmarks include (a) sustained proliferation due to aberrant regulation of growth factor receptor/RTK signaling or cell cycle progression; b dysregulated energetics induced by metabolic reprogramming; c elevated stemness due to the hyperactivation of CSC-related signaling; d enhanced metastasis induced by the overexpression of mesenchymal markers and formation of additional vessels