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. 2020 Apr 15;19:77. doi: 10.1186/s12943-020-01188-4

Table 1.

Some dysregulated LncRNAs and their roles in the progression of HCC

LncRNAs Roles in HCC Binding partners Action modes Outcomes Refs
Dreh Tumor suppressor Vimentin protein Cytoskeleton reorganization

↓ metastasis

↓ proliferation

[24]
ATB Oncogene miR-200 miRNA sponge ↑ metastasis [40]
UFC1 Oncogene

β-catenin mRNA

HuR protein

mRNA stabilization ↑ proliferation [54]
PXN-AS1 Oncogene PXN mRNA mRNA stabilization ↑ proliferation [55]
ANRIL Oncogene

EZH2 protein

Target gene DNA

Transcriptional suppression ↑ proliferation [56]
TUG1 Oncogene

EZH2 protein

Target gene DNA

Transcriptional suppression

↑ proliferation

↑ glycolysis

[57, 58]
lnc-β-Catm Oncogene

EZH2 protein

β-catenin protein

Protein stabilization ↑ stemness [59]
GIHCG Oncogene

EZH2 protein

Target gene DNA

Transcriptional suppression

↑ proliferation

↑ metastasis

[60]
DANCR Oncogene β-catenin mRNA mRNA stabilization ↑ stemness [61]
MALAT1 Oncogene miR-143-3p miRNA sponge

↑ metastasis

↑ proliferation

[62]
HULC Oncogene

miR-186

miR-9

miRNA sponge

↑ proliferation

↑ lipogenesis

[63, 64]
XIST Tumor suppressor miR-92b miRNA sponge

↓ metastasis

↓ proliferation

[65]
PVT1 Oncogene NOP2 protein Protein stabilization ↑ stemness [66]
HOTTIP Oncogene

miR-192

miR-204

miRNA sponge ↑ glutaminolysis [67]
DILC Tumor suppressor IL-6 DNA Transcriptional suppression ↓ stemness [68]
ICR Oncogene ICAM-1 mRNA mRNA stabilization ↑ stemness [69]
ZFAS1 Oncogene miR-150 miRNA sponge ↑ metastasis [70]
MVIH Oncogene PGK1 protein Protein localization ↑ metastasis [71]
CASC9 Oncogene HNRNPL protein Protein phosphorylation ↑ proliferation [72]