Table 1.
Some dysregulated LncRNAs and their roles in the progression of HCC
| LncRNAs | Roles in HCC | Binding partners | Action modes | Outcomes | Refs |
|---|---|---|---|---|---|
| Dreh | Tumor suppressor | Vimentin protein | Cytoskeleton reorganization |
↓ metastasis ↓ proliferation |
[24] |
| ATB | Oncogene | miR-200 | miRNA sponge | ↑ metastasis | [40] |
| UFC1 | Oncogene |
β-catenin mRNA HuR protein |
mRNA stabilization | ↑ proliferation | [54] |
| PXN-AS1 | Oncogene | PXN mRNA | mRNA stabilization | ↑ proliferation | [55] |
| ANRIL | Oncogene |
EZH2 protein Target gene DNA |
Transcriptional suppression | ↑ proliferation | [56] |
| TUG1 | Oncogene |
EZH2 protein Target gene DNA |
Transcriptional suppression |
↑ proliferation ↑ glycolysis |
[57, 58] |
| lnc-β-Catm | Oncogene |
EZH2 protein β-catenin protein |
Protein stabilization | ↑ stemness | [59] |
| GIHCG | Oncogene |
EZH2 protein Target gene DNA |
Transcriptional suppression |
↑ proliferation ↑ metastasis |
[60] |
| DANCR | Oncogene | β-catenin mRNA | mRNA stabilization | ↑ stemness | [61] |
| MALAT1 | Oncogene | miR-143-3p | miRNA sponge |
↑ metastasis ↑ proliferation |
[62] |
| HULC | Oncogene |
miR-186 miR-9 |
miRNA sponge |
↑ proliferation ↑ lipogenesis |
[63, 64] |
| XIST | Tumor suppressor | miR-92b | miRNA sponge |
↓ metastasis ↓ proliferation |
[65] |
| PVT1 | Oncogene | NOP2 protein | Protein stabilization | ↑ stemness | [66] |
| HOTTIP | Oncogene |
miR-192 miR-204 |
miRNA sponge | ↑ glutaminolysis | [67] |
| DILC | Tumor suppressor | IL-6 DNA | Transcriptional suppression | ↓ stemness | [68] |
| ICR | Oncogene | ICAM-1 mRNA | mRNA stabilization | ↑ stemness | [69] |
| ZFAS1 | Oncogene | miR-150 | miRNA sponge | ↑ metastasis | [70] |
| MVIH | Oncogene | PGK1 protein | Protein localization | ↑ metastasis | [71] |
| CASC9 | Oncogene | HNRNPL protein | Protein phosphorylation | ↑ proliferation | [72] |