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. 2020 Apr 9;11:571. doi: 10.3389/fimmu.2020.00571

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Copyright © 2020 Mizuno, Arce, Tomotsune, Albarracin, Funabashi, Vera, Islam, Vizoso-Pinto, Takahashi, Sasaki, Kitazawa and Villena.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of a D-alanyl-lipoteichoic acid biosynthesis protein (dltD) mutant from Lactobacillus plantarum CRL1506 on the inflammatory damage induced by Toll-like receptor 3 (TLR3) activation in mice intestine. Body weight loss and serum biochemical markers lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) in mice orally treated with wild-type (WT) or ΔdltD mutant from L. rhamnosus CRL1506 and challenged with an intraperitoneal injection of the viral molecular associated pattern poly(I:C). Mice with no lactobacilli treatment and challenged with poly(I:C) were used as controls. The results represent data from three independent experiments. Significant differences when compared to the control group: *P < 0.05, **P < 0.01. Significant differences when compared to the indicated group: ^†P < 0.05.