Table 5.
Significantly down-regulated genes in both bone and kidney (GZZSZTW vs. Blank)
| Gene name | Bone | Kidney | ||||||
|---|---|---|---|---|---|---|---|---|
| Blank (FPKM) | GZZSZTW (FPKM) | log2 fold change (GZZSZTW/Blank) | p value | Blank (FPKM) | GZZSZTW (FPKM) | log2 fold change (GZZSZTW/Blank) | p value | |
| Tripartite motif-containing protein 59 (Trim59) | 63.96 | 30.75 | − 1.06 | 4.41E−47 | 3.76 | 0.91 | − 2.05 | 2.92E−11 |
| Collagen alpha-2(VI) chain (Col6a2) | 3.99 | 1.59 | − 1.33 | 5.97E−07 | 6.90 | 1.73 | − 2.00 | 3.15E−25 |
| Lysyl oxidase homolog 1 (Loxl1) | 2.55 | 0.87 | − 1.55 | 2.63E−04 | 6.67 | 3.20 | − 1.06 | 2.23E−07 |
| Rano class II histocompatibility antigen, B alpha chain (Rt1ba) | 16.32 | 4.02 | − 2.02 | 1.59E−13 | 83.32 | 40.73 | − 1.03 | 1.32E−30 |
| 72 kDa type IV collagenase (Mmp2) | 4.72 | 1.68 | − 1.49 | 6.19E−08 | 4.49 | 1.63 | − 1.46 | 1.11E−09 |
| Collagen alpha-1(V) chain (Col5a1) | 1.84 | 0.38 | − 2.28 | 1.27E−09 | 3.71 | 1.35 | − 1.46 | 3.82E−21 |
| Olfactomedin-like protein 3 (Olfml3) | 6.31 | 0.48 | − 3.72 | 2.17E−15 | 7.82 | 2.56 | − 1.61 | 1.51E−10 |
| Mono [ADP-ribose] polymerase PARP16 (Parp16) | 4.18 | 1.65 | − 1.34 | 4.41E−05 | 16.13 | 6.90 | − 1.23 | 1.45E−20 |
| Hemoglobin subunit beta-1 (Hbb1) | 318449.91 | 105658.11 | − 1.59 | 0 | 1173.62 | 298.69 | − 1.97 | 0 |
| Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arntl) | 1.55 | 0.06 | − 4.69 | 2.94E−08 | 12.17 | 1.14 | − 3.42 | 2.01E−60 |
| Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A (Apobec3a) | 0.76 | 0.17 | − 2.16 | 1.95E−04 | 2.11 | 1.00 | − 1.08 | 4.95E−06 |
| Hemoglobin subunit beta-2 (Hbb2) | 25744.68 | 10685.16 | − 1.27 | 0 | 107.40 | 24.59 | − 2.13 | 2.24E−56 |
| Galectin-5 (Lgals5) | 619.97 | 306.05 | − 1.02 | 2.49E−117 | 5.43 | 1.47 | − 1.89 | 8.97E−05 |
| Mitochondrial fission regulator 1 (Mtfr1) | 9.27 | 2.99 | − 1.63 | 4.01E−06 | 22.05 | 10.25 | − 1.11 | 1.90E−09 |
| Solute carrier organic anion transporter family member 2B1 (Slco2b1) | 3.18 | 1.00 | − 1.67 | 6.28E−08 | 3.65 | 1.07 | − 1.77 | 3.73E−13 |
| Macrophage-expressed gene 1 protein (Mpeg1) | 22.34 | 9.15 | − 1.29 | 1.29E−32 | 4.09 | 1.94 | − 1.08 | 5.11E−08 |
| Insulin-like growth factor-binding protein 4 (Igfbp4) | 22.16 | 10.42 | − 1.09 | 7.73E−15 | 80.24 | 20.72 | − 1.95 | 6.94E−157 |
| Decorin (Dcn) | 56.87 | 19.21 | − 1.57 | 2.30E−45 | 87.18 | 20.12 | − 2.12 | 4.97E−145 |
| Calcipressin-1 (Rcan1) | 6.83 | 3.03 | − 1.17 | 5.07E−06 | 46.91 | 23.12 | − 1.02 | 1.38E−33 |
| Phosphoserine aminotransferase (Psat1) | 6.86 | 2.84 | − 1.27 | 2.21E−06 | 191.68 | 64.45 | − 1.57 | 9.36E−259 |
| Selenoprotein P (Sepp1) | 118.47 | 23.76 | − 2.32 | 1.56E−194 | 1943.71 | 875.64 | − 1.15 | 0 |
| Coronin-1C (Coro1c) | 4.42 | 0.61 | − 2.86 | 1.71E−07 | 13.29 | 5.98 | − 1.15 | 1.06E−08 |
| Collagen alpha-1(I) chain (Col1a1) | 198.95 | 66.96 | − 1.57 | 0 | 7.51 | 1.09 | − 2.78 | 1.51E−64 |
| DNA damage-inducible transcript 4 protein (Ddit4) | 7.25 | 2.05 | − 1.82 | 7.97E−09 | 43.56 | 21.42 | − 1.02 | 3.31E−26 |
| Endoglin (Eng) | 3.61 | 0.85 | − 2.09 | 6.83E−09 | 36.46 | 17.26 | − 1.08 | 4.64E−41 |
| Monocarboxylate transporter 1 (Slc16a1) | 40.94 | 18.51 | − 1.15 | 2.32E−32 | 56.75 | 5.62 | − 3.34 | 1.52E−236 |
| Slit homolog 3 protein (Slit3) | 1.32 | 0.28 | − 2.24 | 8.69E−07 | 2.19 | 1.02 | − 1.10 | 6.17E−06 |
| Hephaestin (Heph) | 2.31 | 0.85 | − 1.44 | 1.15E−05 | 3.50 | 1.56 | − 1.17 | 8.10E−09 |
| Caspase-4 (Casp4) | 6.86 | 2.71 | − 1.34 | 9.64E−05 | 5.85 | 2.47 | − 1.24 | 9.73E−05 |
| Carboxypeptidase Q (Cpq) | 7.40 | 1.89 | − 1.97 | 1.29E−09 | 136.94 | 65.28 | − 1.07 | 3.24E−93 |
| Aurora kinase B (Aurkb) | 14.57 | 6.47 | − 1.17 | 1.52E−09 | 0.77 | 0.01 | − 6.27 | 2.34E−04 |
| Complement C1q tumor necrosis factor-related protein 6 (C1qtnf6) | 2.76 | 0.50 | − 2.46 | 5.54E−07 | 1.31 | 0.29 | − 2.18 | 1.81E−04 |
| Glia-derived nexin (Serpine2) | 85.20 | 34.85 | − 1.29 | 1.67E−60 | 8.47 | 1.53 | − 2.47 | 1.82E−22 |
| A disintegrin and metalloproteinase with thrombospondin motifs 2 (Adamts2) | 1.28 | 0.27 | − 2.25 | 5.20E−08 | 1.02 | 0.26 | − 1.97 | 3.48E−05 |
| Glutathione peroxidase 3 (Gpx3) | 186.91 | 71.69 | − 1.38 | 5.73E−109 | 12320.88 | 4891.04 | − 1.33 | 0 |
| Arachidonate 15-lipoxygenase (Alox15) | 34.62 | 13.20 | − 1.39 | 2.33E−32 | 1.61 | 0.10 | − 4.01 | 6.27E−08 |
| Insulin-like growth factor-binding protein 3 (Igfbp3) | 5.44 | 2.70 | − 1.01 | 1.45E−04 | 64.08 | 16.86 | − 1.93 | 9.00E−137 |
| Collagen alpha-1(III) (Col3a1) | 18.19 | 4.02 | − 2.18 | 3.35E−68 | 17.97 | 2.29 | − 2.97 | 6.13E−133 |
| Osteomodulin (Omd) | 7.34 | 0.75 | − 3.29 | 1.52E−16 | 3.64 | 1.41 | − 1.37 | 9.08E−05 |