Table 1. Comparison of the Yields of Acylated Products in the Presence or Absence of K2CO3a.
with K2CO3 (3 equiv) |
without
base |
|||||
---|---|---|---|---|---|---|
product | catalyst (mol %) | time (h) | yield (%) | catalyst (mol %) | time (h) | yield (%) |
2a | 5 | 12 | 79 | 5 | 12 | 39 |
10 | 12 | 87 | 10 | 12 | 53 | |
10 | 1 | 76 | ||||
2b | 5 | 12 | 70 | 10 | 1 | 75 |
2c | 5 | 12 | 76 | 10 | 2 | 87 |
2e | 5 | 12 | 73 | 10 | 1 | 84 |
4a | 5 | 12 | 69 | 10 | 3 | 75 |
4b | 5 | 12 | 70 | 10 | 3 | 85 |
Yields are isolated yields.