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Schematic model of the PVT1/miR-23b-3p/WT1/NF-κB pathway axis in HG-induced proliferation and fibrosis in MCs. HG treatment induced PVT1 expression in MCs. Then, the elevated expression of PVT1 repressed miR-23-3p level and thus protected against WT1 repression. Next, the NF-κB signaling pathway was activated. Finally, the activation of the NF-κB signaling pathway enhanced cell proliferation and fibrosis of HG-induced MCs, which accelerated DN progression
