Table 2.
Oxidative stress, antioxidant enzymes, and inflammation status of the subjects according to TNM stages
| T0 + 1 (n = 45) | T2 (n = 62) | T3 (n = 30) | T4 (n = 57) | |
|---|---|---|---|---|
| Oxidative stress | ||||
| MDA (μM) | 2.77 ± 0.95 (2.62) | 3.10 ± 1.57 (2.81) | 3.03 ± 1.09 (2.69) | 2.63 ± 1.02 (2.41) |
| Antioxidant enzymes | ||||
| SOD (U/mg protein) | 17.29 ± 7.11 (16.43) | 16.68 ± 5.96 (16.31) | 14.83 ± 5.91 (14.88) | 16.53 ± 7.80 (15.65) |
| CAT (U/mg protein) | 16.08 ± 6.71 (16.30) | 16.03 ± 6.30 (14.56) | 12.96 ± 5.39 (12.63)* | 13.41 ± 4.75 (12.77)* |
| GPx (U/mg protein) | 16.40 ± 6.34 (14.49) | 16.23 ± 6.21 (15.18) | 16.08 ± 5.64 (14.99) | 14.81 ± 5.78 (13.72) |
| Inflammation | ||||
| hs-CRP (mg/L) | 1.31 ± 2.81 (0.22) | 0.47 ± 1.08 (0.16) | 1.50 ± 2.96 (0.19) | 2.49 ± 3.74 (0.82)* |
| IL-6 (pg/mL) | 2.53 ± 3.30 (1.36) | 1.96 ± 1.41 (1.45) | 3.43 ± 3.20 (2.09)* | 5.09 ± 4.39 (3.53)* |
1 mean ± SD (median), the data were examined by One-way ANOVA or Kruskal-Wallis test, *p < 0.05. CAT, catalase activity; MDA, malondialdehyde; GPx, glutathione peroxidase; hs-CRP, high sensitivity C-reactive protein; IL-6, interleukin-6; SOD, superoxide dismutase; TNM, tumor-node-metastasis