TABLE 33.5.

Summary of Response for Rescue Protocols^a

PRIVATE Protocol	Number of Animals	Overall Response (%)	Complete Response (%)	Median Response Durationc	Median Duration of Complete Response	References
Actinomycin-D	25	0	0	0 days	0 days	316
Actinomycin-D	49b	41	41	129 days	129 days	310
Dacarbazine	40	35	3	43 days	144 days	313
Dacarbazine or temozolomide-anthracycline	63	71	55	45 days	NR	311
DMAC (dexamethasone, melphalan, actinomycin-D, cytosine arabinoside)	54 86	72 43	44 16	61 days 24 days	112 days NR	309 306
Lomustine (CCNU)	43	27	7	86 days	110 days	314
Lomustine, l-asparaginase, prednisone	48	77	65	70 days	90 days	319
Lomustine, l-asparaginase, prednisone	31	87	52	63 days	111 days	320
Lomustine, DTIC	57	35	23	62 days	83 days	312
Mitoxantrone	44	41	30	NR	127 days	315
MOPP (mechlorethamine, vincristine, procarbazine, prednisone)	117	65	31	61 days	63 days	318
MPP (mechlorethamine, procarbazine, prednisone)	41	34	17	56 days	238 days	317
MOMP (mechlorethamine, vincristine, melphalan, prednisone)	88	51	12	56 days	81 days	301
LOPP (lomustine, vincristine, procarbazine, prednisone)	33	61	36	84 days	NR	302
Vinblastine (second rescue)	39	25.6	7.7	30 days	NR	304
Rabacfosadine (B cell only)	50	74	45	108 days	203 days	270
LPP (lomustine, procarbazine, prednisone)	41	61	29	34 days	84 days	307
Temozolomide	26	32	13	15 days	NR	308

^aMinimum of 25 cases. Few of these protocols include sufficient numbers for adequate statistical power and fewer compare treatment protocols in a randomized prospective fashion. In addition, staging, inclusion, and response criteria vary considerably between protocols presented. Therefore evaluations of efficacy between the various protocols are subject to bias making direct comparisons difficult and indeed precarious.

^bPrednisone often used concurrently.

^cVarious temporal response end-points were used including disease-free interval, time to progression, progression-free survival, time to discontinuation, and remission duration.