TABLE 33.11.

The CHOP-Based Chemotherapy Protocol for Cats with Intermediate/High-grade Lymphoma Employed by the Author

Treatment Week	Drug, Dosage, and Route
1	Vincristine, 0.5–0.7 mg/m2, IV l-Asparaginase, 400 Units/kg, SC Prednisolone, 2.0 mg/kg, PO
2	Cyclophosphamide 200 mg/m2, PO Prednisolone, 2.0 mg/kg, PO
3	Vincristine, 0.5–0.7 mg/m2, IV Prednisolone, 1.0 mg/kg, PO
4	Doxorubicin, 25 mg/m2, IV Prednisolone, 1.0 mg/kg, POa
6	Vincristine, 0.5–0.7 mg/m2, IV
7	Cyclophosphamide 200 mg/m2, PO
8	Vincristine, 0.5–0.7 mg/m2, IV
9b	Doxorubicin, 25 mg/m2, IV
11	Vincristine, 0.5–0.7 mg/m2, IV
13	Cyclophosphamide 200 mg/m2, PO
15	Vincristine, 0.5–0.7 mg/m2, IV
17	Doxorubicin, 25 mg/m2, IV
19	Vincristine, 0.5–0.7 mg/m2, IV
21	Cyclophosphamide 200 mg/m2, PO
23	Vincristine, 0.5–0.7 mg/m2, IV
25c	Doxorubicin, 25 mg/m2, IV

CHOP, Combinations of cyclophosphamide (C), doxorubicin (H, hydroxydaunorubicin), vincristine (O, Oncovin), and prednisolone (P); IV, intravenous; PO, by mouth; SQ, subcutaneous.

Note: A complete blood count (CBC) should be performed before each chemotherapy. If neutrophils are <1500 cells/μL, wait 5–7 days, repeat CBC, then administer the drug if neutrophils have risen above the 1500 cell/μL cutoff.

^aPrednisolone is continued (1 mg/kg, PO) every other day from this point on.

^bIf in complete remission at week 9, continue to week 11.

^cIf in complete remission at week 25, therapy is discontinued after this doxorubicin, and cat is rechecked monthly for recurrence.