TABLE 33.16.

Approximate Frequency of Clinical Diagnostic Abnormalities for Dogs and Cats with Multiple Myeloma (n = 68 cats, 134 dogs)757, 761, 762, 764, 767, 769, 771, 788

Abnormality	Frequency Range Reported (%)
	Dogs	Cats
Increased M component	99	94–98
Monoclonal	95	77–100
Biclonal	5%a	16–23
IgG	40	84
IgA	60	16
Noncutaneous extramedullary extension	NR	65–100b
Marrow plasmacytosis (>10%)	100	50–100
Complete blood count (CBC) abnormalities
Anemia (nonregenerative)	61	50–80
Thrombocytopenia	39	50
Neutropenia	26	37
Circulating plasma cells (leukemia)	7	5–25
Hypoalbuminemia	62	36–60
Hypocholesterolemia	NR	68
Proteinuria	45	71–91
Bence Jones proteinuria	38	40–59
Bone lysis	64	5–45
Serum hyperviscosity	35	35–44
Azotemia	29	22–40
Hypercalcemia	27	10–25
Increased activities of liver enzymes	NR	43–50

NR, Not reported.

^aSeveral single case reports exist for biclonal gammopathy in dogs with MM.

^b11 of 11 in one report had evidence of infiltration in either spleen, lymph node, or liver.