Figure 1.

Effect of anti‐VEGF on the expression of retinal inflammatory mediators, retinal vascular permeability, and retinal leukocyte adhesion. In the control and CNV retina treated with IgG or anti‐VEGF are shown (a–l) mRNA levels of B₁ receptors, B₂ receptors, VEGF‐A, VEGF‐R2, HIF‐1α, IL‐8, IL‐1β, TNF‐α, COX‐2, ICAM‐1, CCL2 and VCAM‐1, (m) Evans blue dye extravasation, (n) representative images of adherent leukocytes in retinal vessels. Scale bar = 100 μm. (o) Number of adherent leukocytes. Data are means ± SEM of values obtained from six rats per group. Ctl, control without lesion; CNV, laser‐induced choroidal neovascularization; IgG, immunoglobulin; *P ≤ .05, significantly different from control + IgG. ⁺ P ≤ .05, significantly different from CNV + IgG. B1R, B2R; B₁ receptors, B₂ receptors