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. 2020 Feb 15;177(9):2143–2162. doi: 10.1111/bph.14974

Figure 7.

Figure 7

Concentration‐dependent effects of local administration of RJR2403 into the reticular thalamic nucleus (RTN) on releases of GABA and L‐glutamate in the motor thalamic nuclei (MoTN) (Study 4). Concentration‐dependent effects of perfusion with (0, 30 and 100 μM) RJR2403 into RTN on extracellular levels of GABA (a, b) and L‐glutamate (d, e) in MoTN of wild type (a, d) and S286L‐TG (b, e). Ordinates indicate mean extracellular levels of GABA and L‐glutamate (μM; N = 6), and abscissas indicate time after RJR2403 administration (min). Grey bars indicate perfusion with RJR2403 into RTN. (c, f) The AUC value of extracellular levels of GABA and L‐glutamate (nmol) during perfusion with RJR2403 (from 20 to 120 min) in panels (a), (b), (d) and (e), respectively. Grey columns in panels (c) and (f) indicate the AUC values of basal extracellular levels of GABA and L‐glutamate in panels (a), (b), (d) and (e). *P < .05 relative to control and # P < .05 relative to wild type by multivariate ANOVA with Tukey's post hoc test