Table 4.
Mean concentrations of anandamide (AEA), palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) in mouse brain 8 hr after oral administration of BIA 10‐2474 and the reference compounds PF‐04457845 and JNJ‐42165279
| Treatment (mg·kg−1 p.o.) | AEA | PEA | OEA |
|---|---|---|---|
| BIA 10‐2474 | |||
| 0.01 | 89.5 ± 9.3 | 107.2 ± 8.8 | 109.1 ± 8.6 |
| 0.03 | 87.0 ± 10.3 | 178.6 ± 62.7 | 143.1 ± 30.6 |
| 0.1 | 136.8 ± 16.4 | 1027.6 ± 148.0 | 676.5 ± 89.8 |
| 0.3 | 172.1 ± 29.5 | 1,223.3 ± 159.6 | 804.0 ± 107.6 |
| PF04457845 | |||
| 0.003 | 88.5 ± 7.5 | 100.6 ± 16.4 | 97.1 ± 8.0 |
| 0.01 | 220.2 ± 46.9 | 984.3 ± 107.1 | 837.5 ± 115.5 |
| 0.03 | 257.6 ± 16.9 | 1073.1 ± 85.1 | 886.1 ± 42.6 |
| 0.1 | 268.7 ± 10.8 | 1080.9 ± 62.0 | 933.4 ± 17.5 |
| 0.3 | 309.4 ± 16.6 | 1,141.9 ± 56.3 | 961.4 ± 48.2 |
| JNJ‐42165279 | |||
| 1 | 89.0 ± 20.6 | 123.4 ± 11.2 | 114.9 ± 13.36 |
| 3 | 83.6 ± 9.1 | 138.3 ± 19.4 | 121.7 ± 10.2 |
| 10 | 86.5 ± 4.8 | 205.6 ± 37.0 | 147.3 ± 13.8 |
| 30 | 95.5 ± 2.5 | 382.2 ± 103.5 | 234.9 ± 46.8 |
Note. Values are expressed as % of control values for n = 4 with SD.