Figure 1.

Losartan (Los) induces different behaviours of the gut microbiota of spontaneously hypertensive rats (SHR). Faecal samples were collected, and bacterial 16S ribosomal DNA was amplified and sequenced to analyse the composition of microbial communities. Phylum breakdown of the five most abundant bacterial communities in the faecal samples obtained from all experimental groups (a). The Firmicutes/Bacteroidetes ratio (F/B ratio) was calculated as a biomarker of gut dysbiosis (b). Relative proportions of acetate‐, butyrate‐, lactate‐, and propionate‐producing bacteria (c). Anaerobic and aerobic bacteria expressed as relative proportions (d) in the gut microbiota in Wistar Kyoto rats (WKY), untreated SHR (SHR) and SHR treated with losartan (SHR‐Los). Values are expressed as mean ± SEM (n = 6). ^* P < .05, significantly different from WKY rats. ^# P < .05 significantly different from untreated SHR