Figure 2.

Losartan (Los) induces improvement of gut inflammation and permeability in spontaneously hypertensive rats (SHR). Colonic mRNA levels of occludin, zonula occludens‐1 (ZO‐1), mucin (MUC)‐2, and MUC‐3 (a). Plasma endotoxin concentrations (endotoxin units·ml⁻¹ [EU·ml⁻¹]) (b). Pro‐inflammatory cytokines, TNF‐α, and IL‐6 (c) in Wistar Kyoto rats (WKY), untreated SHR (SHR), and SHR treated with losartan (SHR‐Los). Values are expressed as mean ± SEM (n = 8). ^* P < .05, significantly different from WKY rats. ^# P < .05, significantly different from untreated SHR rats