Figure 6.

Protective effects of hydralazine (HDZ) in endothelial dysfunction and hypertension in spontaneously hypertensive rats (SHR). Time course of systolic BP (SBP, a) and heart rate (HR, b) measured by tail‐cuff plethysmography in SHR treated with the hydralazine or saline. Morphological data from the left ventricle (c). Endothelium‐dependent relaxation induced by ACh in aortas pre‐contracted by phenylephrine (d) and NADPH oxidase activity measured by lucigenin‐enhanced chemiluminescence (e) in aorta from SHR and SHR + HDZ groups. Values are represented as means ± SEM (n = 8). ^# P < .05, significantly different from untreated SHR