Figure 9.

Effects of faecal microbiota transplantation from spontaneously hypertensive rat (SHR)‐losartan to SHR on vascular function in SHR. Time course of systolic BP (SBP), measured by tail‐cuff plethysmography, in SHR with stool transplant from SHR (S‐S) or from SHR treated with losartan (S‐SLOS, a). Endothelium‐dependent relaxation induced by ACh (ACh) in aortas pre‐contracted by phenylephrine (b) and NADPH oxidase activity measured by lucigenin‐enhanced chemiluminescence in aorta from S‐S, S‐SLOS (c). mRNA levels of regulatory T cells (Treg; FoxP3), T helper (Th‐17; RORγ), Th1 (T‐bet), and Th2 (GATA‐3) cells and mRNA levels of IL‐10, IL‐17a, IFN‐γ, and TNF‐α (d) in aortas from the S‐S and S‐SLOS groups. Values are represented as mean ± SEM. ^# P < .05, significantly different from the S‐S group