Figure 7.

A schematic model depicting MT₂‐mediated NF‐κΒ signalling regulates the functions of bone marrow mesenchymal stem cells (BMMSCs) and the relationship between bone marrow mesenchymal stem cells and osteoclasts in the bone micro‐environment. Melatonin augments the osteogenic differentiation of Bone marrow mesenchymal stem cells and declines the production of RANKL in Bone marrow mesenchymal stem cells by inhibiting MT₂‐mediated NF‐κΒ signalling. Then bone marrow mesenchymal stem cells affect the maturation and functions of osteoclasts via RANKL paracrine secretion