Figure 6.

PepO promotes pulmonary bacterial clearance in C57/BL6 mice. Mice were treated with 10 μg rPepO 6 h before bacterial infection. PBS and LytR were employed as control. (a) PepO significantly reduced the bacteria load of S. pneumoniae D39-infected mice. (b) PepO significantly reduced the bacteria load of an MDR P. aeruginosa-infected mice. (c) In macrophage depleted mice, PepO failed in reducing the bacteria load of D39 infected mice. Data were expressed as mean with SEM (n = 6 mice/group). ns: not significant; *p < 0.05; **p < 0.01; ***p < 0.001. Statistically significant differences were carried out by Student’s t-test.