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Vaccination with Schu S4ΔaroD confers protection against lethal challenge with homologous and heterologous virulent F. tularensis strains.
| Group # | Priming Dose (CFU) | Booster Dose (CFU) | Date of Boost (weeks) | Challenge Dose (CFU) | Challenge Strain | Survival |
|---|---|---|---|---|---|---|
| 1 | - | - | n/a | 42 | Schu S4 | 0/3 |
| 2 | 451 | - | n/a | 42 | Schu S4 | 7/7 |
| 3 | 451 | 5x105 | 5 | 42 | Schu S4 | 7/7 |
| 4 | 451 | 5x105 | 5 | 420 | Schu S4 | 7/7 |
| 5 | 451 | 5x106 | 5 | 420 | Schu S4 | 6/7 |
| 6 | 451 | 5x105 | 5 | 92 | KY99-NR647 | 7/7 |
| 7 | - | - | n/a | 92 | KY99-NR647 | 0/3 |
