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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: J Pediatr. 2020 Jan 24;219:146–151.e1. doi: 10.1016/j.jpeds.2019.12.018

Table 3.

Neurodevelopment at Discharge

Mean (SD) Methadone
(n = 50)
Morphine
(n = 49)
95% CI
(difference)
NNNS summary scores
 Attention 5.16 (1.69) 4.91 (1.34) −0.44, 0.95
 Handling 0.47 (0.32) 0.39 (0.32) −0.06, 0.21
 Regulation 5.24 (0.93) 5.03 (0.86) −0.15, 0.57
 Arousal 4.23 (0.80) 4.29 (0.85) −0.39, 0.27
 Excitability 4.16 (2.72) 4.39 (2.83) −1.33, 0.89
 Lethargy 3.76 (2.10) 3.78 (2.14) −0.86, 0.83
 Hypertonicity 0.52 (1.15) 0.59 (1.00) −0.50, 0.36
 Hypotonicity 0.24 (0.48) 0.14 (0.41) −0.08, 0.27
 Nonoptimal Reflexes 4.38 (2.34) 4.91 (2.07) −1.43, 0.36
 Asymmetric Reflexes 0.55 (1.21) 0.53 (1.00) −0.43, 0.47
 Quality of Movement 4.32 (0.83) 4.40 (0.81) −0.41, 0.24
 Stress Abstinence 0.14 (0.08) 0.14 (0.08) −0.04, 0.03