Table 4.
Neurodevelopment at 18 Month Follow-up
| Mean (SD) | Methadone | Morphine | 95% CI (difference) |
|---|---|---|---|
| Bayley-III | n=47 | n=36 | |
| Cognitive Composite | 100.1 (21.4) | 98.1 (17.2) | −6.61, 10.76 |
| Language Composite | 96.0 (16.9) | 94.2 (18.2) | −5.98, 9.41 |
| Motor Composite | 103.4 (17.2) | 99.1 (17.2) | −3.19, 11.93 |
| Child Behavior Checklist | n=43 | n=34 | |
| Externalizing Problems | 49.3 (11.7) | 49.0 (10.2) | −4.77, 5.34 |
| Internalizing Problems | 45.5 (11.6) | 45.7 (11.3) | −5.43, 5.01 |
| Total Problems | 48.5 (12.1) | 48.5 (11.1) | −5.34, 5.31 |
| Mean (SD) | Atypical Profile | Typical Profiles | 95% CI (difference) |
| Bayley-III | n=21 | n=62 | |
| Cognitive Composite | 95.5 (19.5) | 100.5 (19.7) | −4.83, 14.88 |
| Language Composite | 93.7 (17.1) | 95.7 (17.6) | −6.79, 10.75 |
| Motor Composite | 101.9 (19.1) | 101.4 (16.7) | −9.12, 8.25 |
| Child Behavior Checklist | n=18 | n=59 | |
| Externalizing Problems | 54.2 (11.5) | 47.6 (10.4) | −12.31, −0.84 |
| Internalizing Problems | 51.7 (13.7) | 43.7 (9.9) | −13.89, −2.20 |
| Total Problems | 55.2 (13.4) | 46.4 (10.2) | −14.70, −2.87 |
| Mean (SD) | Phenobarbital at discharge |
No phenobarbital at discharge |
95% CI (difference) |
| Bayley-III | n=16 | n=67 | |
| Cognitive Composite | 89.1 (15.2) | 101.7 (19.9) | 2.02, 23.16 |
| Language Composite | 83.5 (14.8) | 98.0 (16.9) | 5.35, 23.62 |
| Motor Composite | 93.1 (9.87) | 103.5 (18.0) | 1.12, 19.71 |
| Child Behavior Checklist | n=16 | n=61 | |
| Externalizing Problems | 53.5 (11.2) | 48.0 (10.7) | −11.57, 0.54 |
| Internalizing Problems | 51.0 (15.1) | 44.1 (9.8) | −13.06, −0.67 |
| Total Problems | 54.0 (14.6) | 47.1 (10.3) | −13.27, −0.63 |