Skip to main content
. 2019 Dec 16;10(4):603–614. doi: 10.1016/j.apsb.2019.11.015

Figure 7.

Figure 7

CP734 shows little toxicity to main organs. Nude BALB/c mice (13 ± 2 g) were treated with CP734, Gem or vehicle control for 18 days (7 mice/group). All the animals were sacrificed after collecting blood samples from the retroorbital plexus. (A) Complete blood counts were done using AutoHematology Analyzer C-5380 (Mindray). Normal reference ranges for the tested parameters: WBC (2.6–12 × 103/mL), lymphocyte (1.3–9 × 103/mL), hemoglobin (10.1–16.1 g/dL), platelets (5.92–29.72 × 105/mL), and red blood cells (6.5–10.1 × 106/mL). (B) Results of plasma biochemical tests for ALT, AST, ALP, BUN, and creatinine in the control or drug-treated mice. (C) Viscera weight of all groups after mice sacrifice. The values represent the means ± SD of triplicate experiments. (D) H&E staining assay of main tissues after fixation.