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. 2019 Jul 29;10(4):646–666. doi: 10.1016/j.apsb.2019.07.006

Table 1.

Chemical structures of compounds 1–14 and their inhibitory activities of p70S6K phosphorylation.Image 2

Compd.
 R1
 R2
 Inhibition ratio of p70S6K phosphorylation at 20 μmol/L (%)a
NTZ (1) NO2 OAc 50.21±3.11
2 NO2 OH 43.09±2.98
3 NO2 H 64.71±4.20
4 H OAc 9.98±5.16
5 CN OAc 70.85±3.56
6 COOCH3 OAc 32.72±7.87
7 COOBn OAc 18.88±5.27
8 SCH3 OAc 44.74±9.98
9 SO2CH3 OAc 10.67±10.51
10 COOH OAc −4.51±19.40
11 Image 3 OAc 56.27±4.61
12 Image 4 OAc 85.20±1.76
13 Image 5 OAc 69.85±0.53
14 Image 6 OAc 28.21±6.44
a

Results are expressed as the mean ± SD (n ≥ 3).