Table 2.

Chemical structures of compounds 15–54 and their inhibitory activities of phosphorylation of p70S6K.

Compd.	R3	Inhibition ratio of p70S6K phosphorylation at 20 μmol/L (%)a	Compd.	R3	Inhibition ratio of p70S6K phosphorylation at 20 μmol/L (%)a
15		42.25±0.19	36		83.32±0.41
16		21.02±4.56	37		81.20±1.60
17		15.41±5.32	38		80.32±0.71
18		8.76±5.93	39		63.76±1.31
19		53.79±3.85	40		66.21±3.74
20		83.86±1.54	41		63.37±4.65
21		79.20±1.87	42		61.15±1.44
22		88.95±0.78	43		51.10±1.59
23		84.96±0.98	44		26.05±11.29
24		77.51±1.48	45		43.86±4.45
25		22.05±1.85	46		44.98±8.58
26		65.98±1.74	47		61.71±2.51
27		53.24±5.72	48		61.32±5.39
28		55.38±1.66	49		40.38±3.37
29		26.90±6.23	50		61.35±5.44
30		78.75±2.50	51		47.82±3.90
31		80.96±1.60	52		81.60±1.86
32		81.09±4.27	53		44.94±4.00
33		79.80±5.03	54		66.46±3.73
34		80.23±0.88	WORT	–	90.68±1.46
35		79.84±1.17

^aResults are expressed as the mean±SD (n ≥ 3). −Not applicable.