Table 1.
Pharmacokinetic (PK) parameters (mean±SD) of A4 in plasma following tail-vein administration to rats (n = 3).
| PK parameter | Mean ± SD |
|---|---|
| C0 (ng/mL) | 140±75.6 |
| Kel (/h) | 2.30±1.36 |
| t1/2 (h) | 0.385±0.224 |
| MRT0−inf (h) | 0.484±0.303 |
| MRT0–t (h) | 0.320±0.220 |
| AUC0−t (ng·h/mL) | 37.8±18.4 |
| AUC0−inf (ng·h/mL) | 42.9±20.4 |
| CL (mL/kg·min) | 969±610 |
| Vdss (L/kg) | 22.8±9.23 |
C0, initial concentration; Kel, elimination rate constant; t1/2, apparent terminal elimination half-life; MRT0−inf, mean residence time from time 0 extrapolated to infinity; MRT0−t, mean residence time from time 0 to the time of the last quantifiable concentration; AUC0−t, area under the concentration–time curve from time 0 to the time of the last quantifiable concentration; AUC0−inf, area under the concentration–time curve from time 0 extrapolated to infinity; CL, clearance rate; Vdss, steady-state apparent volume of distribution.