Table 4.
Kinase inhibitors for autophagy inhibition.
| Name | Mechanism | Cell line | Disease | Clinical status | Ref. |
|---|---|---|---|---|---|
| LY294002 | PI3K inhibition | Mel Z and Mel IL cells | Neuroblastoma | Phase 1 | 117 |
| Wortmannin | PI3K inhibition | CHO cells | – | – | 118 |
| 3-MA | PI3K inhibition | Mouse embryonic fibroblast | – | – | 119 |
| Dimeric quinacrines | mTORC1/autophagy dual inhibition | PANC1, A375P and C8161 cells | – | – | 120 |
| SBI0206965 | ULK1 inhibition | PDAC cell lines | – | – | 121 |
| MRT67307 | ULK1 inhibition | HeLa cells | – | – | 122 |
| MRT6892 | ULK1 inhibition | HeLa cells | – | – | 122 |
| ULK-101 | ULK1 inhibition | U2OS cells | – | – | 123 |
| SP600125 | JNK inhibition | HT29 cells | – | – | 124 |