Table 3.
Pharmacokinetic parameters of MAGL inhibitor 21 (ABX-1431) in rat and dog.
| Species | Oral Cmax (μmol/L) | Tmax (h) | CL (mL/min/kg) | Vdss (L/kg) | i.v. t1/2 (h) | F (%) |
|---|---|---|---|---|---|---|
| Rat | 0.688 | 8.0 | 14.7 | 3.2 | 3.6 | 64 |
| Dog | 0.777 | 1.0 | 6.3 | 1.2 | 6.1 | 57 |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.