Study	Reason for exclusion
Boye 2011	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ not reported
Colombel 2010	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ not reported
Cosnes 2013	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ not reported
Dewint 2014	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ not reported
Feagan 2003	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ and SF‐36 not reported
Ford 2016	Participants: Data from patients with IDA and underlying gastrointestinal disorders ‐ IBD‐specific data not presented
Hetzel 2013b	Participants: Data from patients with IDA and underlying gastrointestinal disorders ‐ IBD‐specific data not presented
Leiper 2001	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the inflammatory bowel disease quality of life index not reported
Lichtenstein 2002	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ not reported
Loftus 2009	Type of study: Not a RCT. Only presented data from baseline to week 4 prior to commencement of RCT
Loftus 2017	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ or SF‐36 not reported
Maragkoudaki 2016	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IMPACT‐III scale not reported
Mikocka‐Walus 2017	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the WHOQoL not reported
Minderhoud 2007	Type of study: Not a RCT
NCT01991314	Type of study: Not a RCT
NCT02148718	Type of study: Not a RCT
NCT02162862	Type of study: Not a RCT
Paramsothy 2017	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ not reported
Pena Rossi 2009	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ not reported
Persoons 2007	Type of study: Not a RCT
Reusch 2016	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the Short Form‐12 Health Survey not reported
Sands 2008	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ and SF‐36 not reported
Sands 2013	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ and SF‐36 not reported
Schmidt 2016	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ and SF‐36 not reported
Scholten 2018	Participants: Data from patients with IBS and IBD not analysed separately
Schreiber 2007	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ not reported
Smith 2011	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ and SF‐36 not reported
Smith 2013	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IMPACT‐III survey not reported
Steinhart 2002	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ not reported
Szigethy 2016	Type of study: Not a RCT
Targan 2007	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ and SF‐36 not reported
Valentine 2009	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ and SF‐36 not reported
Van Assche 2012	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ not reported
Vermeire 2017	Outcome: Data on fatigue, loss of energy, vigour and vitality as a subscale of the IBDQ or SF‐36 not reported

^{IBD: Inflammatory bowel disease
 IBDQ: Inflammatory Bowel Disease Questionnaire
 IBS: Irritable bowel syndrome
 IDA: Iron deficiency anemia
 RCT: Randomised controlled trial
 SF‐36: 36‐Item Short Form
 WHOQoL: World Health Organisation Quality of Life}