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. 2015 Aug 15;25(5):605–613. doi: 10.1111/bpa.12278

Figure 2.

figure

Pathology of henipavirus infection: vasculopathy in Nipah virus encephalitis showing vasculitis, thrombosis (A) and endothelial multinucleated syncytia with viral inclusion (B, arrow). There are numerous Nipah viral inclusions/antigens within neurons (C), especially around necrotic plaques (D). Necrotic plaques may also have evidence of adjacent vascular thrombo‐occlusion (D, arrow). Vasculitis in Hendra encephalitis may manifest as mild endotheliitis (G). Hendra viral inclusions (H), antigens (F,I) and RNA (E) can be demonstrated in neurons. Viral antigens may also localize to the ependyma (F, arrow). Hematoxylin and eosin stain (A,B,D,G, H). Immunohistochemistry with new fuchsin (C) and DAB (F,I) chromogens, hematoxylin counterstain. In situ hybridization with NBT/BCIP substrate, and hematoxylin counterstain. Original magnification: ×40 (A–I). Permissions were obtained from reference 133 for A and B; reference 136 for C and D; reference 134 for E–I.