Table 1.
Activity in human coronavirus 229E‐infected HEL a cells
| Compounds | Antiviral activity (EC50 b ) | Cytotoxicity (MCC c ) |
|---|---|---|
| 7a | >100 | >100 |
| 7b | >100 | >100 |
| 7c | >100 | >100 |
| 7d | >100 | ≥100 |
| 7e | >100 | >100 |
| 7f | >100 | >100 |
| 7g | >100 | >100 |
| 7h | >100 | >100 |
| 7i | >100 | >100 |
| 7j | >100 | >100 |
| 7k | >100 | >100 |
| 7l | >100 | >100 |
| 7m | 31 ± 1 | >100 |
| 7n | 12 ± 1 | 100 |
| 8a | >100 | >100 |
| 8b | >100 | >100 |
| 8c | >100 | >100 |
| 8d | >100 | >100 |
| 8e | >100 | >100 |
| 8f | >100 | >100 |
| 8g | >100 | >100 |
| 8h | >100 | 100 |
| 8i | >100 | >100 |
| 8j | >100 | >100 |
| 8k | 28 ± 0 | >100 |
| 8l | 18 ± 5 | ≥100 |
| 8m | 8.1 ± 2.2 | 100 |
| 8n | 5.5 ± 0.7 | ≥100 |
| 8o | >100 | >100 |
| 8p | 6.1 ± 0.2 | 50 |
| K22 | 3.3 ± 1.0 | 50 |
Data represent the averages ± SEM of 3–4 independent tests.
HEL: human embryonic lung fibroblast cells.
EC50: compound concentration (µM) producing 50% inhibition of virus replication, as determined by microscopic scoring of the cytopathic effect (CPE).
MCC: minimum cytotoxic concentration (µM), that is, compound concentration producing minimal changes in cell morphology, as estimated by microscopy.
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